MS Infusion Therapy: Ocrevus, Briumvi and Tysabri Explained

Multiple sclerosis (MS) is a condition in which the immune system damages the protective coating around nerves in the brain, spinal cord and optic nerves. Disease-modifying therapies (DMTs) can't cure MS, but they may help reduce relapses, limit new lesions on MRI and slow disability. Several of the most widely used DMTs are given by IV infusion.

Ocrevus (ocrelizumab)

Ocrevus targets B cells, a type of immune cell involved in MS. It's used for relapsing forms of MS and is also approved for primary progressive MS. Treatment starts with two infusions two weeks apart, then one infusion every six months. Medicines are given beforehand to lower the chance of an infusion reaction, and you're monitored during and after.

Briumvi (ublituximab)

Briumvi also targets B cells and is used for relapsing forms of MS. It begins with two starting infusions, then continues every 24 weeks.

Tysabri (natalizumab)

Tysabri works differently, by keeping certain immune cells from crossing into the brain and spinal cord. It's given every four weeks for relapsing MS. A biosimilar, Tyruko, is also available. Tysabri carries a risk of PML, a rare but serious brain infection, so patients are tested for JC virus antibodies and enrolled in a required safety program. Report any new or unusual neurological symptoms to your neurologist right away.

Which one is right for me?

The choice depends on your type of MS, how active it is, your JC virus status, other health conditions, family planning and how often you'd like to come in for treatment. It's a decision to make with your neurologist.

Before your first MS infusion

• Your neurologist will order screening, such as hepatitis B testing for B-cell therapies.
• Review your vaccines, since some should be given before you start.
• Plan for a longer first visit, as starting doses are often given more slowly.
• Bring something to do and dress in comfortable layers.

For more ideas, see our tips for infusion day.

MS infusions in Toms River, NJ

At Infuse Care, MS infusions are given in private suites with nurse monitoring throughout, and we keep your neurologist updated after each visit. Learn more about multiple sclerosis and our neurology services, or call 732-444-8808.