AQP4 Antibody-Positive NMOSD

Learn what AQP4 antibody-positive NMOSD means and how a provider-prescribed infusion therapy may help lower the risk of relapses.

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Therapies we administer

Overview

Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune condition of the central nervous system that mainly affects the optic nerves and the spinal cord. Many people with NMOSD have antibodies against aquaporin-4 (AQP4), a water-channel protein found on support cells in the brain and spinal cord. A positive AQP4 antibody blood test helps confirm the diagnosis and guides treatment. Because each attack can leave lasting damage, long-term care focuses on preventing relapses.

Common Signs and Symptoms

Eye pain with blurred, dimmed or lost vision in one or both eyes
Weakness, numbness or heaviness in the arms or legs
Painful muscle spasms
Changes in bladder or bowel control
Long-lasting hiccups, nausea or vomiting

When to Contact a Provider

New vision loss, sudden weakness or numbness, or a change in bladder control needs prompt medical attention. If you already have NMOSD, tell your neurologist right away about any new or returning symptoms.

How Treatment May Help

Attacks are usually treated quickly with high-dose steroids and, in some cases, plasma exchange. To help prevent future attacks in adults with AQP4 antibody-positive NMOSD, a neurologist may prescribe a targeted therapy.

Uplizna (inebilizumab) targets B cells that help produce the harmful antibodies. It may help lower the risk of relapses.

Therapies That May Be Available at Infuse Care

Uplizna (inebilizumab): IV infusion; two starting doses two weeks apart, then usually one dose every six months

Safety and Monitoring

Uplizna can lower your body's ability to fight infections. Before treatment, your provider will usually test for hepatitis B and tuberculosis and review your vaccines. Infusion reactions can happen, so you are monitored during and after each infusion.

Your prescribing provider decides which treatment is right for you. Infuse Care administers prescribed therapies after a referral, a clinical review and any required insurance authorization, and we keep your provider's office updated on your care.