Common Variable Immune Deficiency (CVID)

Overview

Common variable immune deficiency (CVID) is one of the most frequently diagnosed primary immune deficiencies in adults. In CVID, B cells don't make enough working antibodies. IgG levels are low, and IgA or IgM levels often are too, which leads to repeated infections. It is often diagnosed between ages 20 and 40 but can appear at any age. Some people also develop autoimmune, digestive or lung problems.

Common Signs and Symptoms

• Repeated sinus, ear or lung infections
• More than one episode of pneumonia
• Long-lasting diarrhea or digestive problems
• Autoimmune problems such as low platelet counts
• Swollen lymph nodes or an enlarged spleen

When to Contact a Provider

If you need antibiotics often, or infections keep coming back, ask your provider whether an immunologist should check your antibody levels.

How Treatment May Help

Immunoglobulin replacement therapy supplies the antibodies your body is missing. Given on a regular schedule, it may help lower how often infections occur and how serious they are. It can be given by IV infusion or under the skin, and it is usually lifelong. Infections are treated with antibiotics, and your care team will keep an eye on your lungs and digestive health.

Therapies That May Be Available at Infuse Care

• IVIG (immune globulin intravenous): IV infusion, often every three to four weeks; your immunologist sets the dose based on your IgG levels and infection history

Safety and Monitoring

Headache, chills, tiredness and flushing can occur during or after an infusion. Rare but serious risks include blood clots and kidney problems, so your provider reviews your health history and our nurses adjust the infusion rate and encourage hydration.

Your prescribing provider decides which treatment is right for you. Infuse Care administers prescribed therapies after a referral, a clinical review and any required insurance authorization, and we keep your provider's office updated on your care.