Lupus (Systemic Lupus Erythematosus)

Overview

Systemic lupus erythematosus (SLE) is a long-term autoimmune disease that can affect the skin, joints, kidneys, blood cells, heart, lungs and brain. It tends to alternate between flares and calmer periods. Lupus is most common in women between 15 and 45, and it is more common in Black, Hispanic, Asian and Native American people.

Common Signs and Symptoms

• Fatigue
• Joint pain and swelling
• A rash across the cheeks and nose, or rashes that worsen in the sun
• Unexplained fevers
• Mouth sores
• Hair loss
• Chest pain when taking a deep breath
• Swelling in the legs or foamy urine, which can signal kidney involvement

When to Contact a Provider

See a provider about an unexplained rash, ongoing joint pain or repeated fevers. Chest pain, shortness of breath, seizures or sudden swelling needs urgent care.

How Treatment May Help

Most people with lupus take hydroxychloroquine long term, and some also need steroids or other immune-suppressing medicines. When lupus stays active despite this standard treatment, a rheumatologist may add a biologic medicine. Biologics are used together with standard lupus treatment, not instead of it, and they may help lower disease activity and reduce the number of flares.

Therapies That May Be Available at Infuse Care

• Benlysta (belimumab): IV infusion, with three starting doses two weeks apart and then every four weeks; also available as a weekly injection under the skin. For people with active lupus who are receiving standard therapy, and for active lupus nephritis (lupus affecting the kidneys)
• Saphnelo (anifrolumab): IV infusion every four weeks; also available as a weekly injection under the skin. For adults with moderate to severe lupus who are receiving standard therapy. It is not recommended for severe active lupus nephritis or severe lupus affecting the brain or nerves

Safety and Monitoring

Lupus treatments can raise the risk of infections and need regular blood and urine tests. Benlysta and Saphnelo can cause infusion or allergic reactions, and Saphnelo may raise the risk of shingles; live vaccines are usually avoided during treatment. Tell your provider about any new or worsening depression or mood changes while on Benlysta. Our nurses monitor you during and after each infusion. Sun protection remains an important part of daily care.

Your prescribing provider decides which treatment is right for you. Infuse Care administers prescribed therapies after a referral, a clinical review and any required insurance authorization, and we keep your provider's office updated on your care.