Polyneuropathy (hATTR Amyloidosis)

Overview

Polyneuropathy is damage to many peripheral nerves at once, and it has many causes. This page covers polyneuropathy caused by hereditary transthyretin-mediated amyloidosis (hATTR), an inherited condition in which an abnormal transthyretin (TTR) protein forms amyloid deposits in the nerves, heart and other organs.

Common Signs and Symptoms

• Numbness, tingling or burning that starts in the feet and moves upward
• Weakness in the legs or hands
• Dizziness when standing up
• Diarrhea, constipation or nausea
• Unintended weight loss
• Carpal tunnel syndrome
• Heart rhythm problems or heart failure symptoms

When to Contact a Provider

See a neurologist about numbness or weakness that keeps progressing, especially if a relative has hATTR amyloidosis or you have unexplained heart problems. Genetic testing can confirm the diagnosis.

How Treatment May Help

Gene-silencing medicines lower the amount of TTR protein the liver makes. For adults with hATTR polyneuropathy, they may help slow nerve damage and help preserve daily function.

Therapies That May Be Available at Infuse Care

• Onpattro (patisiran): IV infusion every three weeks
• Amvuttra (vutrisiran): injection under the skin every three months

Safety and Monitoring

Onpattro can cause infusion reactions, so you receive medicines beforehand and are monitored. Both medicines lower vitamin A levels, so a daily vitamin A supplement is usually recommended. Tell your provider about vision changes such as trouble seeing at night. Amvuttra can cause injection-site reactions.

Your prescribing provider decides which treatment is right for you. Infuse Care administers prescribed therapies after a referral, a clinical review and any required insurance authorization, and we keep your provider's office updated on your care.